منابع مشابه
Safety of selective serotonin reuptake inhibitors in pregnancy.
Psychiatric treatment with selective serotonin reuptake inhibitors (SSRIs) may be desirable or necessary during pregnancy; however, the benefit of these treatments must balance the benefits to the mother with any risk to the developing foetus. At the present time, the role of serotonin in normal central nervous system development, as well as the effects of altering serotonin transmission at cri...
متن کاملEndogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives.
Chemoreceptor cells aggregating in clusters in the chicken thoracic aorta contain 5-hydroxytryptamine (5-HT) and have voltage-dependent ion channels and nicotinic acetylcholine receptors, which are characteristics typically associated with neurons. The aim of the present study was to investigate the effects of 5-HT uptake inhibitors, fluvoxamine, fluoxetine and clomipramine (CLM), and amphetami...
متن کاملEffects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neurons.
YM992 [(S)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride] is a selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor (SSRI) and a potent 5-HT(2A) antagonist. The aim of the present study was to assess, using in vivo extracellular unitary recordings, the effect of acute and sustained administration of YM992 (40 mg kg(-1) day(-1) s.c., using osmotic minipumps) on th...
متن کاملSelective Serotonin Reuptake Inhibitors
It has long been postulated that a deficiency in CNS serotonergic activity is the cause of, or a predisposing factor for, depression. [1] However, the evidence for this association is largely circumstantial and it certainly does not represent an adequate and full model for depression, probably due to there being multiple aetiological factors. [2] Some pharmacological trial data also cast doubt ...
متن کاملThe effects of selective serotonin reuptake inhibitors on extracellular 5-HT in the hippo- campus of 5-HT1B receptor knockout mice
The effects of two selective serotonin reuptake inhibitors (SSRIs) on 5-hydroxytryptamine (5-HT) in the hippocampus were studied in wildtype and in 5-HT1B receptor knockout (KO) mice using in vivo microdialysis. Basal 5-HT levels were not different between the two genotypes. The functional absence of 5-HT1B receptors was examined in the knockout mice by local infusion of the 5-HT1B receptor ago...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 1991
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.159.6.885b